Department of Biology

Biology Research

One Health and Biodiversity

The Biology Department has number of scholars interested broadly in themes of One Health and biodiversity who pursue under the C4 BioCluster umbrella research covering:

  • biophotonics applied in cell biology, cancer biology, and environmental systems
  • molecular basis of human diseases including cancer, infectious diseases, autoimmunity and neurological diseases,
  • biotechnology, biosensors, nanoparticle delivery, and bioinformatics

 

C4 BioCluster Research Thrusts

1. Molecular basis of human diseases including cancer, infectious diseases, autoimmunity and neurological diseases.

Representative publications

  • Nuta O, Rothkamm K, Darroudi F. The Role of Telomerase in Radiation-Induced Genomic Instability. Radiat Res. 2020 Mar 9. doi: 10.1667/RR15495.1.
  • Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent  action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 May 15;146(10):2822-2828. doi: 10.1002/ijc.32658.
  • Schroeder R, Grzywa R, Wirtz CR, Sienczyk M, Burster T. Application of a novel FAM-conjugated activity-based probe to determine cathepsin G activity intracellularly. Anal Biochem. 2020;588:113488. doi:10.1016/j.ab.2019.113488.
  • Myngbay A, Bexeitov Y, Adilbayeva A, Assylbekov Z, Yevstratenko BP, Aitzhanova RM, Matkarimov B, Adarichev VA, Kunz J. CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis. Front Immunol. 2019 Jun 12;10:1353. doi: 10.3389/fimmu.2019.01353.
  • Andreeva A, Bekkhozhin Z, Omertassova N, Baizhumanov T, Yeltay G, Akhmetali M, Toibazar D, Utepbergenov D. The apparent deglycase activity of DJ-1 results from  the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals. J Biol Chem. 2019 Dec 6;294(49):18863-18872, doi: 10.1074/jbc.RA119.011237
  • Shevtsova E, Vergnaud G, Shevtsov A, Shustov A, Berdimuratova K, Mukanov K, Syzdykov M, Kuznetsov A, Lukhnova L, Izbanova U, Filipenko M, Ramankulov Y. Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide  Diversity. Front Microbiol. 2019 Aug 13;10:1897. doi: 10.3389/fmicb.2019.01897.
  • Dammann F, Kirschstein T, Guli X, Müller S, Porath K, Rohde M, Tokay T, Köhling R. Bidirectional shift of group III metabotropic glutamate receptor-mediated synaptic depression in the epileptic hippocampus. Epilepsy Res. 2018 Jan;139:157-163. doi: 10.1016/j.eplepsyres.2017.12.002.
2. Biophotonics applied in cell biology, cancer biology, and environmental systems.
Representative publications:
  • Veremeyko T, Kuznetsova IS, Dukhinova M, W Y Yung A, Kopeikina E, Barteneva NS, Ponomarev ED. Neuronal extracellular microRNAs miR-124 and miR-9 mediate cell-cell communication between neurons and microglia. J Neurosci Res. 2019;97(2):162‐184. doi:10.1002/jnr.24344
  • Pham TT, Monnard A, Helenius J, Lund E, Lee N, Müller DJ, Cabernard C. Spatiotemporally Controlled Myosin Relocalization and Internal Pressure Generate Sibling Cell Size Asymmetry. iScience. 2019 Mar 29;13:9-19. doi: 10.1016/j.isci.2019.02.002.
  • Potashnikova DM, Golyshev SA, Penin AA, Logacheva MD, Klepikova AV, Zharikova AA, Mironov AA, Sheval EV, Vorobjev IA. FACS Isolation of Viable Cells in Different Cell Cycle Stages from Asynchronous Culture for RNA Sequencing. Methods Mol Biol. 2018;1745:315-335. doi: 10.1007/978-1-4939-7680-5_18.
  • Dashkova V, Clapper J, Vorobjev IA, Barteneva NS. Spectral and Imaging Flow Cytometry in Phytoplankton Research. Methods Mol Biol. 2018;1745:83-95. doi:10.1007/978-1-4939-7680-5_5
  • Trifonova RT, Barteneva NS. Quantitation of IRF3 Nuclear Translocation in Heterogeneous Cellular Populations from Cervical Tissue Using Imaging Flow Cytometry. Methods Mol Biol. 2018;1745:125-153.
  • Guney M, Yagofarova A, Yapiyev V, Schönbach C, Kim JR, Inglezakis VJ. Distribution of potentially toxic soil elements along a transect across Kazakhstan. Geoderma Regional. 2020; 21, e00281. doi.org/10.1016/j.geodrs.2020.e00281
  • Roubinet C, Tsankova A*, Pham TT*, Monnard A, Caussinus E, Affolter M, Cabernard C. Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells. Nat Commun. 2017 Nov 9;8(1):1383. doi: 10.1038/s41467-017-01391-w.*equal contribution
3. Biotechnology and bioinformatics including nanoparticle delivery, biosensors, and biological data mining.

Representative publications

  • Sypabekova M, Dukenbayev K, Tsepke A, Akisheva A, Oralbayev N, Kanayeva D. An aptasensor for the detection of Mycobacterium tuberculosis secreted immunogenic protein MPT64 in clinical samples towards tuberculosis detection. Sci Rep. 2019 Nov 7;9(1):16273. doi: 10.1038/s41598-019-52685-6
  • Xie Y, Fan H, Lu W, Yang Q, Nurkesh A, Yeleussizov T, Maipas A, Lu J, Manarbek L, Chen Z, Benassi E. Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene. 2019 Apr;38(16):2967-2983. doi: 10.1038/s41388-018-0608-2
  • Ranganathan S, Gribskov M, Nakai K, Schönbach C (Editors-in-Chief). Encyclopedia of Bioinformatics and Computational Biology (The A to Z of Bioinformatics). Volume 1-3, 1st Edition. pp. 1-3284, Elsevier, 2019.  ISBN (ebook): 978-0-128-114322; August 31, 2018; ISBN (Print): ISBN 978-0-128-114148. January 1, 2019.
  • Sun X, Shi Y, Akahoshi T, Fujiwara M, Gatanaga H, Schönbach C, Kuse N, Appay V, Gao GF, Oka S, Takiguchi M. Effects of a Single Escape Mutation on T Cell and  HIV-1 Co-adaptation. Cell Rep. 2016 Jun 7;15(10):2279-2291. doi: 10.1016/j.celrep.2016.05.017.
  • Sayyar B, Dodd M, Marquez-Curtis L, Janowska-Wieczorek A, Hortelano G. Fibronectin-Alginate microcapsules improve cell viability and protein secretion of encapsulated Factor IX-engineered human mesenchymal stromal cells. Artif Cells Nanomed Biotechnol. 2015;43(5):318-27. doi.org/10.3109/21691401.2014.885446

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