Dos Sarbassov
Position:
Professor
Office Phone:
70 5873
E-mail:
Website:
CV:
Research Interest
a nutrient-dependent cell growth, ribosomal biogenesis, assembly of preribosomal complexes, a nutrient-dependent cell signaling and its deregulation in cancer, cancer therapeutics
Biography
Selected Publications
Courses Offered
In 1991 he graduated from the biological faculty of the Kazakh State University. In 1997 he defended his doctoral dissertation in biochemistry and molecular biology at the University of Arkansas for Medical Sciences.
- Kim D-H, Sarbassov DD, Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. (2002) mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175. PMID: 12150925
- Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. (2005) Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science 307(5712):1098-1101. PMID: 15718470
- Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Current Biology 14(14):1296-302. PMID: 15268862
- Sarbassov, D.D., Ali, S.M., Sabatini, D.M. Growing roles for the mTOR pathway (2005) Current Opinion in Cell Biology, 17 (6), pp. 596-603.
- Chen CH, Shaikenov T, Pererson TR, Aimbetov R, Bissenvbaev AK, Lee SW, Wu J, Lin HK, Sarbassov DD. (2011) ER stress inhibits mTORC2 and Akt signaling through GSK-3beta mediated phosphorylation of rictor. Sci Signal 4(ra10). PMID: 2134361
- Abetov DA, Kiyan VS, Zhylkibayev AA, Sarbassova DA, Alybayev SD, Spooner E, Song MS, Bersimbaev RI, Sarbassov DD. Formation of mammalian pre-ribosomes proceeds from intermediate to composed state during ribosome maturation. J Biol Chem. 2019 May 10. pii: jbc.AC119.008378. doi: 10.1074/jbc. AC119.008378. [Epub ahead of print] PMID: 31076509. (the manuscript has been selected as Editors’ Pick)
- Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 May 15;146(10):2822-2828. doi: 10.1002/ijc.32658. Epub 2019 Oct 8.PMID: 31472018
BIOL 425 Biomedical Research Methods
BIOL 592 Research Seminar
