Казахско-американский биолог. Известен как один из первооткрывателей роли белка MTOR в росте, пролиферации клеток, транскрипции мРНК и биосинтезе белков внутри клеток^[1].

В 1991 году окончил биологический факультет Казахского государственного университета. В 1997 году защитил докторскую диссертацию по биохимии и молекулярной биологии в Медицинском университете Арканзаса (University of Arkansas for Medical Sciences).

1. Kim D-H, Sarbassov DD, Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. (2002) mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175. PMID: 12150925

2. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. (2005) Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science 307(5712):1098-1101. PMID: 15718470

3.  Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Current Biology 14(14):1296-302. PMID: 15268862

4.  Sarbassov, D.D., Ali, S.M., Sabatini, D.M. Growing roles for the mTOR pathway (2005) Current Opinion in Cell Biology, 17 (6), pp. 596-603.

5.  Chen CH, Shaikenov T, Pererson TR, Aimbetov R, Bissenvbaev AK, Lee SW, Wu J, Lin HK, Sarbassov DD. (2011) ER stress inhibits mTORC2 and Akt signaling through GSK-3beta mediated phosphorylation of rictor.  Sci Signal 4(ra10). PMID: 2134361

6.   Abetov DA, Kiyan VS, Zhylkibayev AA, Sarbassova DA, Alybayev SD, Spooner E, Song MS, Bersimbaev RI, Sarbassov DD. Formation of mammalian pre-ribosomes proceeds from intermediate to composed state during ribosome maturation. J Biol Chem. 2019 May 10. pii: jbc.AC119.008378. doi: 10.1074/jbc. AC119.008378. [Epub ahead of print] PMID: 31076509. (the manuscript has been selected as Editors’ Pick)

7.  Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 May 15;146(10):2822-2828. doi: 10.1002/ijc.32658. Epub 2019 Oct 8.PMID: 31472018

BIOL 425 Biomedical Research Methods

BIOL 592 Research Seminar